Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Diaminocyclohexane, trans- → 1-(3-Fluoro-4-methoxy-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| 반응물 | 1-(4-Methylpyridin-3-yl)imidazolidin-2-one | HCID 59636170 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-(3-Fluoro-4-methoxy-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one | HCID 59636171 | 86.2% |
반응 단계
Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8474 mmol) was reacted with 4-bromo-2-fluoro-1-methoxy-benzene (191 mg, 0.932 mmol), 1,4-dioxane (20 mL), copper iodide (16 mg, 0.08474 mmol), trans-1,2-diamino cyclohexane (29.4 mg, 0.2542 mmol) and potassium phosphate (449 mg, 2.11 mmol) to afford 220 mg of the product (86% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045173E1 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-51cd44c75a394dba97314f672693a99b |
| 출처 메모 | uspto-grants-2014_09 |