1,2-Diaminocyclohexane, trans- → HCID 68784517, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Diaminocyclohexane, trans-	HCID 43806	—
반응물	Potassium Phosphate, Tribasic	HCID 62657	—
반응물	2-Acetamido-5-bromopyridine	HCID 293097	—
반응물	1-(4-Methylpyridin-3-yl)imidazolidin-2-one	HCID 59636170	—
촉매	Copper iodide	HCID 83717	—
용매	1,4-Dioxane	HCID 31275	—
생성물	HCID 68784517	HCID 68784517	40%

반응 단계

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8465 mmol) was reacted with N-(5-bromo-pyridin-2-yl)-acetamide (217.4 mg, 1.016 mmol), 1,4-dioxane (20 mL), copper iodide (16 mg, 0.08474 mmol), trans-1,2-diamino cyclohexane (29.4 mg, 0.254 mmol) and potassium phosphate (449.7 mg, 2.118 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 105 mg of the product (40% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	USRE045173E1
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-6e37a01c006841c28f62715785e4b30a
출처 메모	uspto-grants-2014_09