Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 1-Benzothiazol-6-yl-3-(2-chloro-ethyl)-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 반응물 | 6-Aminobenzothiazole | HCID 68288 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 1-Benzothiazol-6-yl-3-(2-chloro-ethyl)-urea | HCID 68783928 | 80.2% |
반응 단계
1-Chloro-2-isocyanato-ethane (2.1 g, 19.99 mmol) was added drop wise to a stirred solution of benzothiazol-6-ylamine (2 g, 13.33 mmol) in toluene (80 mL) over a period of 15 minutes at 0° C. The reaction mixture was stirred at room temperature for 18 hours. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 2.73 g (80.2% yield) of 1-benzothiazol-6-yl-3-(2-chloro-ethyl)-urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045173E1 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-9a27a19cc0fb4bdd947be7c9edab7123 |
| 출처 메모 | uspto-grants-2014_09 |