1,2-Diaminocyclohexane, trans- → 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Diaminocyclohexane, trans-	HCID 43806	—
반응물	Potassium Phosphate, Tribasic	HCID 62657	—
반응물	2-Bromo-5-chlorotoluene	HCID 84476	—
반응물	1-(4-Methylpyridin-3-yl)imidazolidin-2-one	HCID 59636170	—
촉매	Copper iodide	HCID 83717	—
용매	1,4-Dioxane	HCID 31275	—
생성물	1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one	HCID 59636163	78.43%

반응 단계

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8474 mmol) was reacted with 1-bromo-4-chloro-2-methyl-benzene (174 mg, 0.8474 mmol), 1,4-dioxane (5 mL), copper iodide (16.19 mg, 0.08474 mmol), trans-1,2-diamino cyclohexane (29.1 mg, 0.2542 mmol) and potassium phosphate (539.63 g, 2.542 mmol) to afford 200 mg of the product (78.43% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	USRE045173E1
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-0e5e9c1de47348c7a4bc82dc0edd9da8
출처 메모	uspto-grants-2014_09