1,2-Diaminocyclohexane, trans- → 2-Fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Diaminocyclohexane, trans-	HCID 43806	—
반응물	Potassium Phosphate, Tribasic	HCID 62657	—
반응물	4-Bromo-2-fluorobenzaldehyde	HCID 143517	—
반응물	1-(4-Methylpyridin-3-yl)imidazolidin-2-one	HCID 59636170	—
촉매	Copper iodide	HCID 83717	—
용매	1,4-Dioxane	HCID 31275	—
생성물	2-Fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde	HCID 59636164	59.2%

반응 단계

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 300 mg, 1.694 mmol) was reacted with 4-bromo-2-fluoro-benzaldehyde (403 mg, 2.118 mmol), 1,4-dioxane (25 mL), copper iodide (32.186 mg, 0.1694 mmol), trans-1,2-diamino cyclohexane (72.16 mg, 0.5082 mmol) and potassium phosphate (1.077 g, 5.082 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% MeOH in CHCl3) afforded 300 mg of 2-Fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde (59.05% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	USRE045173E1
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-1b2fa23761714a5ca6494edf7fb5ff0a
출처 메모	uspto-grants-2014_09