Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one
반응식
C([O-])(=O)C.[Na+].Br[CH2:7][C:8](=[O:11])[CH2:9][CH3:10].[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1.C(OCC)(=O)C>CO.CCCCCC>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][CH2:7][C:8](=[O:11])[CH2:9][CH3:10])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1참가 물질
7
실험 절차
Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).
후처리
- customThe resulting reaction mass
- filtrationThe reaction mixture was filtered
- customthe solid collected
- customwas dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-71203114ad6d41cfaacd277bb5ec8620
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- USRE045173E1
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