Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one

HRID 80221

반응식

HRID 80221 반응식
C([O-])(=O)C.[Na+].Br[CH2:7][C:8](=[O:11])[CH2:9][CH3:10].[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1.C(OCC)(=O)C>CO.CCCCCC>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][CH2:7][C:8](=[O:11])[CH2:9][CH3:10])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

참가 물질

7

반응물 4

HCID 8857Ethyl AcetateHCID 131561-Bromo-2-butanoneHCID 682886-AminobenzothiazoleHCID 517045Sodium Acetate

생성물 1

HCID 596361951-(Benzothiazol-6-ylamino)-butan-2-one수율 34.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8058Hexane용매

실험 절차

Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).

후처리

  1. customThe resulting reaction mass
  2. filtrationThe reaction mixture was filtered
  3. customthe solid collected
  4. customwas dried under reduced pressure

출처 및 근거

ORD 기록
ord-71203114ad6d41cfaacd277bb5ec8620
출처 데이터셋
uspto-grants-2014_09
특허 번호
USRE045173E1

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