Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 3-Amino-4-picoline | HCID 137935 | — |
| 반응물 | 1-Chloro-2-isocyanato-2-methyl-propane | HCID 11040747 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea | HCID 68785605 | 97.1% |
반응 단계
4-Methyl-pyridin-3-ylamine (1.98 g, 18.33 mmol) was added to solution of 1-chloro-2-isocyanato-2-methyl-propane (I-200c: 3 g, 20.40 mmol) in toluene (30 mL). The resulting mixture was stirred at room temperature for 3 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was filtered and the residue was dried to afford 4.3 g of the product (87.75% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045173E1 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b07c728c21cb48b78444794a121a8a1f |
| 출처 메모 | uspto-grants-2014_09 |