1-Phenethylamine, (+)- → (R)-3-(1-phenylethylamino)methylenedihydrofuran-2-one

반응식

[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[C:10]1([C@H:16]([NH2:18])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([C@H:16]([NH:18][CH:3]=[C:4]2[CH2:8][CH2:7][O:6][C:5]2=[O:9])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 6431891-Phenethylamine, (+)-

HCID 66988753HCID 66988753, 화합물

생성물 1

HCID 66988015(R)-3-(1-phenylethylamino)methylenedihydrofuran-2-one수율 71%

실험 절차

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (50 mmol) and (R)-1-phenylethylamine (55 mmol) and proceeding according to the abovementioned method A1, (R)-3-(1-phenylethylamino)methylenedihydrofuran-2-one (7.70 g, efficiency: 71%) is produced in the form of a white powder.

출처 및 근거

ORD 기록: ord-0853b7b310a54b17a1c21a43e4ef34ed
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846125B2

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