4-(Dimethylamino)phenylboronic acid → N-{4-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}-N,N-dimethylamine

HRID 80422

반응식

HRID 80422 반응식
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[CH3:19][N:20]([CH3:30])[C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1>>[N:11]12[CH2:17][CH:15]3[CH2:14][CH:13]([CH2:18][CH:9]([N:8]([C:4]4[CH:3]=[C:2]([C:24]5[CH:25]=[CH:26][C:21]([N:20]([CH3:30])[CH3:19])=[CH:22][CH:23]=5)[CH:7]=[N:6][CH:5]=4)[CH2:16]3)[CH2:10]1)[CH2:12]2

참가 물질

3

반응물 2

HCID 27343444-(Dimethylamino)phenylboronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

생성물 1

HCID 68781672N-{4-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}-N,N-dimethylamine

실험 절차

The title compound was prepared from the product of Example 65A and 4-dimethylaminophenylboronic acid according to General Method B: 1H NMR (500 MHz, CDCl3) δ ppm 8.15 (s, 1 H), 8.03 (s, 1 H), 7.48 (d, 2 H), 7.06 (s, 1 H), 6.80 (d, 2 H), 3.73-3.35 (m, 7 H), 3.06-3.03 (m, 8 H), 2.27-2.17 (m, 3 H), 2.04-1.79 (m, 3 H), 1.88-1.77 (m, 3 H); LC-MS Method D (ESI+) m/z 349.0 (M+H)+, retention time 1.24 minutes.

출처 및 근거

ORD 기록
ord-88692ce069404861affc19b25dd0f2ea
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846661B2

연결된 노트

불러오는 중…