Phenylboronic Acid → 4-(5-Phenylpyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80426

반응식

HRID 80426 반응식
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[C:19]1(B(O)O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:19]1([C:2]2[CH:3]=[C:4]([N:8]3[CH2:16][CH:15]4[CH2:17][N:11]5[CH2:12][CH:13]([CH2:18][CH:9]3[CH2:10]5)[CH2:14]4)[CH:5]=[N:6][CH:7]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 66827Phenylboronic AcidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

생성물 1

HCID 498694304-(5-Phenylpyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

실험 절차

The title compound was prepared from the product of Example 65A and phenylboronic acid according to General Method B: 1H NMR (500 MHz, CDCl3) δ ppm 6 ppm 8.14 (d, 2 H), 7.56 (d, 2 H), 7.46 (t, 2 H), 7.39 (t, 1 H), 7.10 (s, 1 H), 3.73-3.37 (m, 5 H), 3.05-2.97 (m, 3 H), 2.27-2.17 (m, 4 H), 1.88-1.77 (m, 3 H); LC-MS Method D (ESI+) m/z 306.0 (M+H)+, retention time 1.28 minutes.

출처 및 근거

ORD 기록
ord-599af1c2b56545d7a37f30bc44d1b743
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846661B2

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