2-Acetylphenylboronic acid → 1-{2-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}ethanone

HRID 80453노트

반응식

HRID 80453 반응식
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[C:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O)(=[O:21])[CH3:20]>>[N:11]12[CH2:17][CH:15]3[CH2:14][CH:13]([CH2:18][CH:9]([N:8]([C:4]4[CH:3]=[C:2]([C:23]5[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=5[C:19](=[O:21])[CH3:20])[CH:7]=[N:6][CH:5]=4)[CH2:16]3)[CH2:10]1)[CH2:12]2

참가 물질

3

반응물 2

HCID 27343092-Acetylphenylboronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

생성물 1

HCID 498697181-{2-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}ethanone

실험 절차

The title compound was prepared from the product of Example 65A and 2-acetylphenylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 348.0 (M+H)+, retention time 1.26 minutes.

출처 및 근거

ORD 기록
ord-b8d2b596116b447fb4343f3317b908e0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846661B2

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