Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Methoxyphenyl)boronic acid → 4-[5-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Methoxyphenyl)boronic acid | HCID 201262 | — |
| 반응물 | 4-(5-Bromo-1,3-thiazol-2-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane | HCID 86649262 | — |
| 생성물 | 4-[5-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane | HCID 86649261 | — |
반응 단계
The title compound was prepared from the product of Example 105A and 4-methoxyphenylboronic acid according to General Method C: 1H NMR (500 MHz, CDCl3) δ ppm 7.35 (d, 2 H), 7.28 (s, 1 H), 6.88 (d, 2 H), 4.75-4.71 (m, 1 H), 3.64-3.59 (q, 2 H), 3.48-3.40 (q, 2 H), 3.08-3.05 (m, 4 H), 2.29-2.18 (m, 3 H), 1.88-1.80 (m, 3 H); LC-MS Method D (ESI+) m/z 342.0 (M+H)+, retention time 1.44 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846661B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-75e1bac8b619483ebd476d563ce6b07e |
| 출처 메모 | uspto-grants-2014_09 |