Dichloromethane → 3'-(((4-(2-Bromo-4-fluorophenyl)piperidin-4-yl)methoxy)methyl)-5'-(trifluoromethyl)biphenyl-4-carbonitrile

HRID 804926

반응식

HRID 804926 반응식
[Br:1][c:2]1[c:3]([C:9]2([CH2:22][O:23][CH2:24][c:25]3[cH:26][c:27](-[c:35]4[cH:36][cH:37][c:38]([C:41]#[N:42])[cH:39][cH:40]4)[cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[cH:30]3)[CH2:10][CH2:11][N:12]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:13][CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Cl:43][CH2:44][Cl:45].[OH:46][C:47]([C:48]([F:49])([F:50])[F:51])=[O:52]>>[Br:1][c:2]1[c:3]([C:9]2([CH2:22][O:23][CH2:24][c:25]3[cH:26][c:27](-[c:35]4[cH:36][cH:37][c:38]([C:41]#[N:42])[cH:39][cH:40]4)[cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[cH:30]3)[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58993540Tert-butyl 4-(2-bromo-4-fluorophenyl)-4-(((4'-cyano-5-(trifluoromethyl)biphenyl-3-yl)methoxy)methyl)piperidine-1-carboxylate

생성물 1

HCID 589934843'-(((4-(2-Bromo-4-fluorophenyl)piperidin-4-yl)methoxy)methyl)-5'-(trifluoromethyl)biphenyl-4-carbonitrile

출처 및 근거

ORD 기록
ord-352f012d5d724f9fb4e24fae51c1d5ea
출처 데이터셋
Test data from https://doi.org/10.1039/C8SC04228D

연결된 노트

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