참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Ammonium Carbonate | HCID 517111 | — |
| 반응물 | 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene | HCID 22014733 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Nitro-5-(3-diethylamino-1-propoxy)aniline | HCID 22014718 | — |
반응 단계
The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07087632B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-2376017b04d24493a40d98ac5b74b779 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
