Ethyl Acetate → 2-Nitro-5-(3-diethylamino-1-propoxy)aniline

HRID 8050

반응식

HRID 8050 반응식
F[C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C(=O)([O-])[O-].[NH4+:24].[NH4+].CCOC(C)=O>CN(C=O)C>[N+:17]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:7][C:2]=1[NH2:24])([O-:19])=[O:18]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 517111Ammonium CarbonateHCID 220147332-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

생성물 1

HCID 220147182-Nitro-5-(3-diethylamino-1-propoxy)aniline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

후처리

  1. washThe combined organic layers are then washed with water and brine
  2. dry with materialdried over Na2SO4
  3. customRemoval of the solvent in vacuo

출처 및 근거

ORD 기록
ord-2376017b04d24493a40d98ac5b74b779
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087632B2

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