참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Fluoro-4-nitrophenol | HCID 520948 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-Benzyloxy-2-fluoro-1-nitrobenzene | HCID 22180704 | — |
반응 단계
(Bromomethyl)benzene (10.9 g, 63.7 mmol) and 3-fluoro-4-nitrophenol (10 g, 63.7 mmol) were added to 150 mL acetone followed by potassium carbonate (8.8 g, 63.7 mmol) and sodium iodide (9.54 g, 63.7 mmol). The reaction mixture was heated at 55° C. overnight. The resulting mixture was filtered and concentrated. The crude material was recrystallized in ethyl acetate/hexane to give the title compound. MS (DCI+) m/z 264.9 (M+NH4)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846663B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-9602a878ebc942c498254a3c05a59c9e |
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| 출처 메모 | uspto-grants-2014_09 |
|---|
