Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
[4-(Pyrrolidin-1-yl)piperidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone → {4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | [4-(Pyrrolidin-1-yl)piperidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone | HCID 57886103 | — |
| 반응물 | 7-Bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 86659422 | — |
| 생성물 | {4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone | HCID 67007432 | — |
반응 단계
The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and [4-(pyrrolidin-1-yl)piperidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone using Suzuki coupling conditions as described in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846664B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5ae53c1928c840c18e000d1c3e701170 |
| 출처 메모 | uspto-grants-2014_09 |