(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine → [(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone

HRID 80552

반응식

HRID 80552 반응식
[CH3:1][C:2]1([CH3:18])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=2)[O:3]1.[NH:19]1[CH2:23][CH2:22][CH2:21][C@@H:20]1[CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:25]1([CH2:24][C@H:20]2[CH2:21][CH2:22][CH2:23][N:19]2[C:13]([C:12]2[CH:11]=[CH:10][C:9]([B:4]3[O:5][C:6]([CH3:7])([CH3:8])[C:2]([CH3:1])([CH3:18])[O:3]3)=[CH:17][CH:16]=2)=[O:15])[CH2:29][CH2:28][CH2:27][CH2:26]1

참가 물질

3

반응물 2

HCID 853151(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27346214-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

생성물 1

HCID 54578782[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone

실험 절차

[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone was prepared as described in Example 14 from 4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoic acid and (R)-(−)-1-(2-pyrrolidinylmethyl)pyrrolidine.

출처 및 근거

ORD 기록
ord-7dbf6fefa38540f4b3e370c51561ef14
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846664B2

연결된 노트

불러오는 중…