tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate → 2-Hydroxymethyl-4-(5-{1-[4-(1-hydroxy-1-methyl-ethyl)-2-trifluoromethyl-benzyl]-1H-indazol-5-ylmethylene}-4-oxo-4,5-dihydro-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

반응식

[C:35]([CH3:36])([CH3:37])([CH3:38])[O:39][C:40](=[O:41])[N:42]1[CH:43]([CH2:48][OH:49])[CH2:44][NH:45][CH2:46][CH2:47]1.[CH2:1]([S:2][C:4]1=[N:8][C:7](=[O:9])[C:6](=[CH:10][c:11]2[cH:12][c:13]3[cH:14][n:15][n:16]([CH2:20][c:21]4[c:22]([C:31]([F:32])([F:33])[F:34])[cH:23][c:24]([C:27]([CH3:28])([CH3:29])[OH:30])[cH:25][cH:26]4)[c:17]3[cH:18][cH:19]2)[S:5]1)[CH3:3]>>[C:4]1([N:45]2[CH2:44][CH:43]([CH2:48][OH:49])[N:42]([C:40]([O:39][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:41])[CH2:47][CH2:46]2)=[N:8][C:7](=[O:9])[C:6](=[CH:10][c:11]2[cH:12][c:13]3[cH:14][n:15][n:16]([CH2:20][c:21]4[c:22]([C:31]([F:32])([F:33])[F:34])[cH:23][c:24]([C:27]([CH3:28])([CH3:29])[OH:30])[cH:25][cH:26]4)[c:17]3[cH:18][cH:19]2)[S:5]1