Pyridine → 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 8063

반응식

HRID 8063 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][NH2:8].[CH2:9]([O:11][C:12](=[O:20])[CH:13]([C:17](=O)[CH3:18])[C:14](=O)[CH3:15])[CH3:10].N1C=CC=CC=1>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[C:14]([CH3:15])=[N:8][N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:17]=1[CH3:18])=[O:20])[CH3:10]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 786452-HydrazinopyridineHCID 79063Ethyl 2-acetylacetoacetate

생성물 1

HCID 98562563,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Similar to Example 1, 2-pyridylhydrazine (7.5 mmol, 0.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (7.5 mmol, 1.3 g) were mixed in a solution of 50% pyridine in ethanol, then heated under reflux. The solvents were removed under vacuum and the residue purified over silica. The named product crystallized upon standing (m.p. 49° C.–50° C.).

후처리

  1. temperatureheated
  2. temperatureunder reflux
  3. customThe solvents were removed under vacuum
  4. customthe residue purified over silica
  5. customThe named product crystallized

출처 및 근거

ORD 기록
ord-d66dcc09bc84436bab5835d34320f478
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087634B2

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