Pyridine → ethyl 1-(3-fluorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate

HRID 8070

반응식

HRID 8070 반응식
Cl.[F:2][C:3]1[CH:4]=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[CH2:11]([O:13][C:14](=[O:22])[CH:15]([C:19](=O)[CH3:20])[C:16](=O)[CH3:17])[CH3:12].N1C=CC=CC=1>C(O)C>[CH2:11]([O:13][C:14]([C:15]1[C:16]([CH3:17])=[N:10][N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([F:2])[CH:4]=2)[C:19]=1[CH3:20])=[O:22])[CH3:12]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 79063Ethyl 2-acetylacetoacetateHCID 27239143-Fluorophenylhydrazine hydrochloride

생성물 1

HCID 9856538ethyl 1-(3-fluorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Similar to Example 1, equimolar amounts of 3-fluorophenylhydrazine hydrochloride and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of 50% pyridine in ethanol. Analysis showed that resulting solid was the named product (m.p. 55° C.–56.1° C.).

후처리

  1. customthat resulting solid

출처 및 근거

ORD 기록
ord-50a50e2c29a64a198360ea13b9febfaf
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087634B2

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