Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Amino-3-chloropyridazine → 6-(4-Benzylpiperazin-1-yl)pyridazin-3-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| 반응물 | 1-Benzylpiperazine | HCID 75994 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 6-(4-Benzylpiperazin-1-yl)pyridazin-3-ylamine | HCID 59367712 | 82.2% |
반응 단계
48.9 g (278 mmol) of 1-benzylpiperazine and 12.0 g (92.6 mmol) of 3-amino-6-chloropyridazine are heated at 160° C. for 1 hour. The brown oil obtained is poured into 500 mL of aqueous sodium bicarbonate solution and the product is extracted with dichloromethane. The organic phase is dried and then concentrated under reduced pressure. The oil obtained is triturated in diethyl ether, and 20.5 g of a solid are isolated after filtering off and drying.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846676B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-365f660cdcd04b8c95be9d01d77f0cb0 |
| 출처 메모 | uspto-grants-2014_09 |