Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 80723생성일: 2026년 10월 23일
Hydrochloric Acid → 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine
https://huagongshe.com/ko/reaction/80723
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Benzyloctahydropyrrolo[3,4-c]pyrrole | HCID 4454387 | — |
| 반응물 | 6-Chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine | HCID 59367714 | — |
| 용매 | 1-Pentanol | HCID 6276 | — |
| 생성물 | 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine | HCID 59406971 | — |
반응 단계
A mixture of 3.00 g (10.9 mmol) of 6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine and 6.6 g (33 mmol) of 2-benzyloctahydropyrrolo[3,4-c]pyrrole in 20 mL of pentanol is heated at 150° C. for 2 days in a reactor. The medium is then poured into aqueous 1N hydrochloric acid solution. The aqueous phase is washed with ethyl acetate and then basified with sodium hydroxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846676B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-ae878798158d46dfae2ba814ab27e8f7 |
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| 출처 메모 | uspto-grants-2014_09 |
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