6-Amino-3-chloropyridazine → 6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

HRID 80735

반응식

HRID 80735 반응식
Br[CH:2]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:17][C:18]1[N:23]=[N:22][C:21]([NH2:24])=[CH:20][CH:19]=1>C(O)C>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[N:22]([C:2]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)=[C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:24]=2)[N:23]=1

참가 물질

4

반응물 2

HCID 216436-Amino-3-chloropyridazineHCID 134660102-Bromo-1-phenyl-2-pyrid-4-ylethanone

생성물 1

HCID 594069546-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 13 g (36.5 mmol) of 2-bromo-1-phenyl-2-pyrid-4-ylethanone (CAS No.: 741633-76-1) and 18.9 g (146 mmol) of 6-chloropyridazin-3-ylamine in 200 mL of ethanol is maintained at 90° C. for 5 hours 30 minutes. After cooling, the solvent is evaporated off under reduced pressure, the medium is taken up in 50 mL of water and the product is extracted with ethyl acetate. The organic phases are dried over magnesium sulfate and then concentrated under reduced pressure.

후처리

  1. temperatureAfter cooling
  2. customthe solvent is evaporated off under reduced pressure
  3. extractionthe product is extracted with ethyl acetate
  4. dry with materialThe organic phases are dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3197f8470dfc43b6a117c10cf499bc10
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846676B2

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