Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 80736생성일: 2026년 10월 23일
4-(1-Pyrrolidinyl)piperidine → 2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine
https://huagongshe.com/ko/reaction/80736
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| 반응물 | 6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine | HCID 59406954 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine | HCID 59406955 | — |
반응 단계
A mixture of 4.03 g (13.1 mmol) of 6-chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine and 4.4 g (29 mmol) of 4-pyrrolidin-1-ylpiperidine in 50 mL of ethanol is heated at 155° C. for 4 hours. After cooling, the solvent is evaporated off under reduced pressure and the residue is chromatographed on silica gel, eluting with a mixture of dichloromethane and methanol (93:7).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846676B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-c2eb2d7b1f2042a3af4bc5b0db2ec5b6 |
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| 출처 메모 | uspto-grants-2014_09 |
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