Pyridine → 3-Methoxy-N-[6-(4-acetylpiperazin-1-yl)-4-benzylamino-3-cyanoquinolin-2-yl]benzamide

반응식

[CH3:31][O:32][c:33]1[cH:34][c:35]([C:36](=[O:37])[Cl:38])[cH:39][cH:40][cH:41]1.[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([N:22]3[CH2:23][CH2:24][N:25]([C:28]([CH3:29])=[O:30])[CH2:26][CH2:27]3)[cH:8][c:9]2[c:10]([NH:14][CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[c:11]1[C:12]#[N:13].[cH:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1>>[NH:1]([c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([N:22]3[CH2:23][CH2:24][N:25]([C:28]([CH3:29])=[O:30])[CH2:26][CH2:27]3)[cH:8][c:9]2[c:10]([NH:14][CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[c:11]1[C:12]#[N:13])[C:36]([c:35]1[cH:34][c:33]([O:32][CH3:31])[cH:41][cH:40][cH:39]1)=[O:37]

참가 물질

반응물 3

HCID 1049Pyridine

HCID 74374m-Anisoyl chloride

HCID 670236072-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline

생성물 1

HCID 670236583-Methoxy-N-[6-(4-acetylpiperazin-1-yl)-4-benzylamino-3-cyanoquinolin-2-yl]benzamide

출처 및 근거

ORD 기록: ord-e2af8500ae854240a69d048260c9e181
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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