1-((1-Methyl-4-piperidinyl)methyl)piperazine → 4-{6-[4-(1-Methylpiperidin-4-ylmethyl)piperazin-1-yl]pyridazin-3-yl}benzonitrile, hydrochloride

HRID 80883노트

반응식

HRID 80883 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[CH3:16][N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:19][CH2:18]1>>[ClH:1].[CH3:16][N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][N:24]2[CH2:29][CH2:28][N:27]([C:2]3[N:3]=[N:4][C:5]([C:8]4[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=4)=[CH:6][CH:7]=3)[CH2:26][CH2:25]2)[CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 27369421-((1-Methyl-4-piperidinyl)methyl)piperazineHCID 64052563-Chloro-6-(4-cyanophenyl)pyridazine

생성물 1

HCID 684907804-{6-[4-(1-Methylpiperidin-4-ylmethyl)piperazin-1-yl]pyridazin-3-yl}benzonitrile, hydrochloride

실험 절차

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(4-cyanophenyl)pyridazine and (1-methylpiperidin-4-ylmethyl)piperazine.

출처 및 근거

ORD 기록
ord-9b420e15bedd4a7486fcc4dea77ea4ab
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846677B2

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