Triethylamine → 2-[4-(Propan-2-yl)piperazin-1-yl]pyrazine

HRID 80911노트

반응식

HRID 80911 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[CH:15]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([CH3:17])[CH3:16]>CC(C)=O>[CH:15]([N:18]1[CH2:23][CH2:22][N:21]([C:2]2[CH:7]=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:20][CH2:19]1)([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 73277ChloropyrazineHCID 780131-Isopropylpiperazine

생성물 1

HCID 206138392-[4-(Propan-2-yl)piperazin-1-yl]pyrazine

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
120 °C

실험 절차

Chloropyrazine (2.3 g, 20 mmol) and triethylamine (3 g, 30 mmol) were mixed in acetone (8 mL) in a 20 mL microwave vessel. 1-Isopropylpiperazine (2.8 g, 22 mmol) was added and the reaction mixture was heated for 3300 seconds at 120° C. in a microwave oven. The reaction mixture was evaporated and the residue was purified on a silicagel column with dichloromethane/MeOH (9:1) as eluent. Yield: 1.64 g solid 4-isopropyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl.

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified on a silicagel column with dichloromethane/MeOH (9:1) as eluent

출처 및 근거

ORD 기록
ord-b5f8cac1319e4245bd119027756037e5
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846677B2

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