Piperazine → 2-(Piperazin-1-yl)-1,3-thiazole-5-carboxylic acid
반응식
Br[C:2]1(C(O)=O)[NH:6][CH:5]=[CH:4][S:3]1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:16]([O-])([O-:18])=[O:17].[K+].[K+]>O1CCOCC1>[N:10]1([C:2]2[S:3][C:4]([C:16]([OH:18])=[O:17])=[CH:5][N:6]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1참가 물질
5
실험 절차
2-Bromothiazole carboxylic acid 1 (1 g; 4.8 mmol) and piperazine (6.2 g; 72 mmol; 24 equiv.) were dissolved in dioxane, K2CO3 (3.32 g; 24 mmol; 5 equiv.) was added and the suspension was refluxed over night. The solvent was removed at the rotary evaporator, the residue dissolved in ethanol, filtered and recrystallized. The crude product was dried at the oil pump and directly used in the following step.
후처리
- temperaturethe suspension was refluxed over night
- customThe solvent was removed at the rotary evaporator
- dissolutionthe residue dissolved in ethanol
- filtrationfiltered
- customrecrystallized
- dry with materialThe crude product was dried at the oil pump
출처 및 근거
- ORD 기록
- ord-540876f9926548bb87ef494dd0757107
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846682B2
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