Triethylamine → 3-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

HRID 80947

반응식

HRID 80947 반응식
CCN(CC)CC.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=1.Cl[CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22]>O1CCCC1>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH:17][CH2:19][CH2:20][C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:22])[CH3:16])=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 702953-ChloropropiophenoneHCID 1550852(S)-(-)-1-(4-chlorophenyl)ethylamine

생성물 1

HCID 581093723-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

후처리

  1. concentrationThen, the solution was concentrated
  2. additionwater (100 mL) was added to the residue
  3. extractionthe resulting mixture was extracted with tert-butyl methyl ether
  4. washThe combined organic extracts were washed with water and brine
  5. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-b09480803c8b4742aeba444bd87fdb27
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846668B2

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