Water → 3-Hydroxy-4-methoxy-3-phenyl-butyraldehyde

HRID 80960노트

반응식

HRID 80960 반응식
[CH3:1][O:2][CH2:3][C:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([OH:10])[CH2:5][CH:6]([OH:9])CO.O>ClCCl>[OH:10][C:4]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)([CH2:3][O:2][CH3:1])[CH2:5][CH:6]=[O:9]

참가 물질

4

반응물 2

HCID 962Water2회HCID 596356585-Methoxy-4-phenyl-pentane-1,2,4-triol

생성물 1

HCID 596356773-Hydroxy-4-methoxy-3-phenyl-butyraldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

NaIO4 (5.20 g) was added to a mixture of 5-methoxy-4-phenyl-pentane-1,2,4-triol (1.10 g), dichloromethane (10 mL), and water (5 mL) chilled in an ice bath. The mixture was stirred vigorously while warming to ambient temperature in the cooling bath and further stirred at this temperature overnight. Then, water (20 mL) and dichloromethane (50 mL) were added, the organic layer was separated, and the aqueous layer was extracted with dichloromethane (2×25 mL). The combined organic phases were washed with water and dried (MgSO4). After removal of the solvent, the title compound was obtained which was used without further purification.

후처리

  1. temperaturechilled in an ice bath
  2. stirringfurther stirred at this temperature overnight
  3. customthe organic layer was separated
  4. extractionthe aqueous layer was extracted with dichloromethane (2×25 mL)
  5. washThe combined organic phases were washed with water
  6. dry with materialdried (MgSO4)
  7. customAfter removal of the solvent

출처 및 근거

ORD 기록
ord-37939e7cb09549d3aa4500f76fe52e74
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846668B2

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