Water → Tert-butyl 4-(6-(5-(3-fluoro-2-(2-hydroxy-2-phenylpentylcarbamoyl)pyridin-4-ylthio)thiazol-2-ylamino)pyridin-3-ylamino)piperidine-1-carboxylate

반응식

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[cH:16][cH:17][c:18]([NH:21][c:22]3[s:23][c:24]([S:27][c:28]4[c:29]([F:37])[c:30]([C:34](=[O:35])[OH:36])[n:31][cH:32][cH:33]4)[cH:25][n:26]3)[n:19][cH:20]2)[CH2:12][CH2:13]1.[CH3:51][CH2:52][N:53]=[C:54]=[N:55][CH2:56][CH2:57][CH2:58][N:59]([CH3:60])[CH3:61].[CH3:72][N:73]1[CH2:74][CH2:75][CH2:76][C:77]1=[O:78].[NH2:38][CH2:39][C:40]([CH2:41][CH2:42][CH3:43])([OH:44])[c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1.[OH2:79].[OH:62][n:63]1[c:64]2[c:65]([cH:66][cH:67][cH:68][cH:69]2)[n:70][n:71]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[cH:16][cH:17][c:18]([NH:21][c:22]3[s:23][c:24]([S:27][c:28]4[c:29]([F:37])[c:30]([C:34](=[O:35])[NH:38][CH2:39][C:40]([CH2:41][CH2:42][CH3:43])([OH:44])[c:45]5[cH:46][cH:47][cH:48][cH:49][cH:50]5)[n:31][cH:32][cH:33]4)[cH:25][n:26]3)[n:19][cH:20]2)[CH2:12][CH2:13]1