Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloroaniline → 4-chloro-N-(2-(diethylamino)ethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloroaniline | HCID 7812 | — |
| 반응물 | 2-Bromoethyldiethylammonium bromide | HCID 70607 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 4-chloro-N-(2-(diethylamino)ethyl)aniline | HCID 224501 | — |
반응 단계
4-Chloro-aniline (0.5 g, 3.9 mmol) was added to a solution of 2-bromo-N,N-diethylethylamine hydrobromide (1.12 g, 4.3 mmol) and N,N-diisopropylethylamine (2 mL, 11.7 mmol) in toluene (7.8 mL). The mixture was stirred at room temperature for 5 hours. The mixture was then diluted with EtOAc (30 mL) and saturated NaHCO3 (20 mL). The organic layer was washed with H2O (1×20 mL), dried (Na2SO4), filtered and concentrated to give 4-chloro-N-(2-(diethylamino)ethyl)benzenamine as an oil which was used without purification. MS (APCI+) [M+H]+ 227.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846683B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-fec6c0e3f3594fb2967b4d59a791e720 |
| 출처 메모 | uspto-grants-2014_09 |