Hydrazine → HCID 178509239, 화합물

HRID 81022노트

반응식

HRID 81022 반응식
Cl[C:2]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:18][CH:17]=2)[C:3]=1[C:4]#[N:5].[NH2:29][NH2:30]>>[O:22]([C:19]1[CH:18]=[CH:17][C:16]([C:6]2[CH:7]=[C:8]([N:10]3[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]3)[N:9]=[C:2]3[NH:29][N:30]=[C:4]([NH2:5])[C:3]=23)=[CH:21][CH:20]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

3

반응물 2

HCID 9321HydrazineHCID 866656832-Chloro-4-(4-phenoxyphenyl)-6-(piperidin-1-yl)nicotinonitrile

생성물 1

HCID 178509239HCID 178509239, 화합물

실험 절차

Following conditions described in Step 4 of Example 8, 2-chloro-4-(4-phenoxyphenyl)-6-(piperidin-1-yl)nicotinonitrile was reacted with hydrazine to give Example 9. 1H NMR (400 MHz, methanol-d4) δ ppm 7.47-7.65 (2H, m), 7.32-7.48 (2H, 7.15 (1H, t, J=7.40 Hz), 6.97-7.08 (2H, m), 6.96-7.13 (4H, m), 6.41 (1H, s), 3.52-3.73 (4H, m), 1.50-1.76 (6H, m). MS (ES+) m/z: 386 (M+H); LC retention time: 3.501 min (analytical HPLC Method A).

후처리

  1. customto give Example 9

출처 및 근거

ORD 기록
ord-f66a184c65414c6eac94bdc8bafca51e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846673B2

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