Methyl vinyl sulfone → {2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester
반응식
[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]([CH3:28])([CH3:27])[CH2:9][C:10]1[C:18]2[C:13](=[C:14](CS(C(F)(F)F)(=O)=O)[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[CH:30]([S:32]([CH3:35])(=[O:34])=[O:33])=[CH2:31]>>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]([CH3:27])([CH3:28])[CH2:9][C:10]1[C:18]2[C:13](=[C:14]([CH:31]=[CH:30][S:32]([CH3:35])(=[O:34])=[O:33])[CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)([CH3:2])([CH3:4])[CH3:3]참가 물질
3
실험 절차
{2-[7-(2-Methanesulfonyl-vinyl)-1H-indol-3-yl)-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester is prepared from [1,1-dimethyl-2-(7-trifluoromethanesulfonylmethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester and methyl vinyl sulfone as described for the preparation of Amine 23 (98%). FDMS m/e=392.2 (M++1).
출처 및 근거
- ORD 기록
- ord-6bb9173e2bfb4e009592dee1e206c9e3