Tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate → Tert-butyl (3-amino-2,6-dichloropyridin-4-yl)carbamate
반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH:5]=[C:4]([Cl:19])[N:3]=1>C(O)C.O.[Fe]>[NH2:8][C:7]1[C:2]([Cl:1])=[N:3][C:4]([Cl:19])=[CH:5][C:6]=1[NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17]참가 물질
5
실험 절차
A mixture of tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate (700 g, 2.27 mol) and iron (1272.7 g, 22.7 mol) in ethanol (5 L) and water (1 L) was stirred at room temperature for 10 h. The mixture was filtered, the filtrate was concentrated in vacuo, and the crude product was crystallized using EtOAc to give tert-butyl (3-amino-2,6-dichloropyridin-4-yl)carbamate.
후처리
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
- customthe crude product was crystallized
출처 및 근거
- ORD 기록
- ord-7057e44afc3840a58f7b467c63e2741f
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846657B2
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