2,4-Dimethoxypyrimidine-5-boronic acid pinacol ester → 2-(2,4-dimethoxypyrimidin-5-yl)-4-morpholino-6-((4-N-phenylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidine

반응식

[CH3:33][O:34][c:35]1[n:36][cH:37][c:38]([B:43]2[O:44][C:45]([CH3:46])([CH3:47])[C:48]([CH3:49])([CH3:50])[O:51]2)[c:39]([O:41][CH3:42])[n:40]1.[c:1]1([S:7](=[O:8])(=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][c:17]3[cH:18][c:19]4[n:20][c:21]([Cl:32])[n:22][c:23]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)[c:24]4[s:25]3)[CH2:14][CH2:15]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([S:7](=[O:8])(=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][c:17]3[cH:18][c:19]4[n:20][c:21](-[c:38]5[cH:37][n:36][c:35]([O:34][CH3:33])[n:40][c:39]5[O:41][CH3:42])[n:22][c:23]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)[c:24]4[s:25]3)[CH2:14][CH2:15]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

참가 물질

반응물 2

HCID 162183882,4-Dimethoxypyrimidine-5-boronic acid pinacol ester

HCID 866235146-(4-Benzenesulfonyl-piperazin-1-ylmethyl)-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

생성물 1

HCID 582338612-(2,4-dimethoxypyrimidin-5-yl)-4-morpholino-6-((4-N-phenylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidine

출처 및 근거

ORD 기록: ord-d54a6ebe5db14a8d8035ae860a0c4271
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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