Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate → 4-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

HRID 81136노트

반응식

HRID 81136 반응식
[CH3:1][O:2][CH:3]1[CH2:7][N:6](C(OCC2C=CC=CC=2)=O)[CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][CH:3]1[CH2:7][NH:6][CH:5]([C:18]2([O:21][CH3:22])[CH2:20][CH2:19]2)[CH2:4]1

참가 물질

5

반응물 2

HCID 86724494Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 867244954-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate (141 mg, 0.462 mmol) dissolved in ethyl acetate (3.1 mL) was added palladium on carbon (49.1 mg, 0.05 mmol). Hydrogen gas was added via balloon and the reaction was stirred at room temperature for 3 hours. The mixture was filtered over celite and concentrated under reduced pressure to afford 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine.

후처리

  1. filtrationThe mixture was filtered over celite and
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-42d9d219fb804727a47f3f298fb60684
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846657B2

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