benzyl (2R)-5-methoxy-2-methylpiperidine-1-carboxylate → (2R)-5-methoxy-2-methylpiperidine
반응식
[CH3:1][O:2][CH:3]1[CH2:8][N:7](C(OCC2C=CC=CC=2)=O)[C@H:6]([CH3:19])[CH2:5][CH2:4]1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][CH:3]1[CH2:8][NH:7][C@H:6]([CH3:19])[CH2:5][CH2:4]1참가 물질
5
실험 절차
To benzyl (2R)-5-methoxy-2-methylpiperidine-1-carboxylate (345 mg, 1.31 mmol) dissolved in ethyl acetate (6.5 mL) was added palladium on carbon (139 mg, 0.13 mmol). Hydrogen gas was added via balloon, and the reaction was stirred at room temperature for 3 hours. The mixture was filtered over celite and concentrated under reduced pressure to afford (2R)-5-methoxy-2-methylpiperidine. 1H NMR (500 MHz, DMSO-d6) δ 3.33 (s, 3H), 3.23-3.13 (m, 2H), 2.66-2.59 (m, 1H), 2.03-1.97 (m, 1H), 1.47-1.40 (m, 1H), 1.39-1.28 (m, 2H), 1.08-1.04 (m, 3H), 0.91-0.79 (m, 2H).
후처리
- filtrationThe mixture was filtered over celite and
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-da68e188e1184401a1155ec3ec4d1575
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846657B2
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