2-Cyanopyrimidine-5-boronic acid pinacol ester → 5-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyrimidine-2-carbonitrile

HRID 813157

반응식

HRID 813157 반응식
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:25])[n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]3)[cH:17]1)[CH:7]([CH3:26])[CH2:6]2.[CH3:27][C:28]1([CH3:29])[C:30]([CH3:31])([CH3:32])[O:33][B:34]([c:35]2[cH:36][n:37][c:38]([C:41]#[N:42])[n:39][cH:40]2)[O:43]1>>[c:2]1(-[c:35]2[cH:36][n:37][c:38]([C:41]#[N:42])[n:39][cH:40]2)[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:25])[n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]3)[cH:17]1)[CH:7]([CH3:26])[CH2:6]2

참가 물질

3

반응물 2

HCID 164142762-Cyanopyrimidine-5-boronic acid pinacol esterHCID 594023174-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

생성물 1

HCID 594023385-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}pyrimidine-2-carbonitrile

출처 및 근거

ORD 기록
ord-07a7bd96c1b34791916886299098e9e3
출처 데이터셋
Test data from https://doi.org/10.1039/C8SC04228D

연결된 노트

불러오는 중…