4-(tert-Butylaminosulphonyl)benzeneboronic acid → N-tert-Butyl-4-{1-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-benzenesulfonamide

반응식

[C:24]([CH3:25])([CH3:26])([CH3:27])[NH:28][S:29](=[O:30])(=[O:31])[c:32]1[cH:33][cH:34][c:35]([B:38]([OH:39])[OH:40])[cH:36][cH:37]1.[I:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1>>[c:2]1(-[c:35]2[cH:34][cH:33][c:32]([S:29]([NH:28][C:24]([CH3:25])([CH3:26])[CH3:27])(=[O:30])=[O:31])[cH:37][cH:36]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1

참가 물질

반응물 2

HCID 221071704-(tert-Butylaminosulphonyl)benzeneboronic acid

HCID 574687852-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

생성물 1

HCID 57468929N-tert-Butyl-4-{1-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-benzenesulfonamide

출처 및 근거

ORD 기록: ord-2109f949f6a543849c95a02fa38cecd8
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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