참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Dimethylazanide | HCID 182180 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 78% |
반응 단계
A catalytic amount (1 ml) of N,N-dimethylamide was added to 2-amino-4-fluorobenzoic acid (50 g, 322 mmol) and formamide (77 ml, 1934 mmol), and the resulting solution was stirred. The solution was heated to 180° C. and stirred for 14 hours. The temperature of the solution was cooled to room temperature, and 300 ml of distilled water was added thereto. The resulting solid was stirred about 30 min, and filtered to obtain the title compound 41.3 g (yield: 78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846699B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-c6d31f2832c24e03bae54d8181808b82 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
