Sodium Carbonate → (3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

HRID 81474

반응식

HRID 81474 반응식
[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C([O-])([O-])=O.[Na+].[Na+].[Br:22]Br>C(O)(=O)C>[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][C:5]([Br:22])=[CH:6][N:7]=1

참가 물질

5

반응물 3

HCID 10340Sodium Carbonate2회HCID 24408Bromine2회HCID 68630652(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone

생성물 1

HCID 86634541(3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

실험 절차

(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone (1.00 g, 4.99 mmol) is dissolved in glacial acetic acid (10 ml). Na2CO3 (0.583 g, 5.49 mmol) is added. After evolution of gas has finished, a solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml) is added dropwise. Na2CO3 (0.583 mg, 5.49 mmol) is added, followed by a second solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml). The resulting orange suspension is left to stir for 1 hour. The reaction is quenched by pouring onto ice water (150 ml), and the orange solid formed is collected by filtration, washed with water and dried in vacuo at 40° C. overnight to yield the title compound. [M+H]+ 279.

후처리

  1. waitThe resulting orange suspension is left
  2. customThe reaction is quenched
  3. additionby pouring onto ice water (150 ml)
  4. customthe orange solid formed
  5. filtrationis collected by filtration
  6. washwashed with water
  7. customdried in vacuo at 40° C. overnight

출처 및 근거

ORD 기록
ord-2df8dadc6d6444069182564d5bc89b78
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846687B2

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