Morpholine → 4-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 81484노트

반응식

HRID 81484 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)(=[O:10])=[O:9])[CH:7]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 866319035-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

생성물 1

HCID 686302274-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

후처리

  1. washwashed with 0.1M HCl
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-45708f4f8412433482efb34a2569e6cb
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846687B2

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