Water → 5-Bromo-3-chloropyrazin-2-amine

HRID 81495

반응식

HRID 81495 반응식
[Cl:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=1.C(=O)([O-])[O-].[Na+].[Na+].[Br:15]Br.O>C(O)(=O)C>[Br:15][C:6]1[N:7]=[C:2]([Cl:1])[C:3]([NH2:8])=[N:4][CH:5]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 10340Sodium Carbonate2회HCID 24408Bromine2회HCID 2762242-Amino-3-chloropyrazine

생성물 1

HCID 467382025-Bromo-3-chloropyrazin-2-amine

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

실험 절차

3-Chloro-pyrazin-2-ylamine (0.750 g, 5.79 mmol) is suspended in acetic acid (7 ml) with stirring at room temperature and sodium carbonate (0.675 g, 6.37 mmol) is added. When all the gas has evolved bromine (0.171 ml, 3.34 mmol) in acetic acid (4 ml) is added dropwise. Sodium carbonate (0.675 g, 6.37 mmol) is added and a gas evolves. Once all gas has evolved bromine (0.171 ml, 3.34 mmol) in acetic acid (4 ml) is added. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is poured onto iced water and left to stir for 30 minutes. A pale yellow suspension has formed. This solid is filtered off and rinsed with cold water to give 5-Bromo-3-chloro-pyrazin-2-ylamine.

후처리

  1. additionis added dropwise
  2. additionis added
  3. stirringThe reaction mixture is stirred at room temperature for 1 hour
  4. waitleft
  5. stirringto stir for 30 minutes
  6. customA pale yellow suspension has formed
  7. filtrationThis solid is filtered off
  8. washrinsed with cold water

출처 및 근거

ORD 기록
ord-6070ba6a7f884eb59c1475f9ac09e9a1
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846687B2

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