3-Ethynylimidazo[1,2-b]pyridazine → N-(4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide

반응식

[C:1](#[CH:2])[c:3]1[cH:4][n:5][c:6]2[n:7]1[n:8][cH:9][cH:10][cH:11]2.[OH:12][CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:21][c:22]2[c:23]([C:39]([F:40])([F:41])[F:42])[cH:24][c:25]([NH:28][C:29]([c:30]3[cH:31][c:32]([I:37])[c:33]([CH3:36])[cH:34][cH:35]3)=[O:38])[cH:26][cH:27]2)[CH2:19][CH2:20]1>>[C:1](#[C:2][c:32]1[cH:31][c:30]([C:29]([NH:28][c:25]2[cH:24][c:23]([C:39]([F:40])([F:41])[F:42])[c:22]([CH2:21][N:18]3[CH2:17][CH2:16][N:15]([CH2:14][CH2:13][OH:12])[CH2:20][CH2:19]3)[cH:27][cH:26]2)=[O:38])[cH:35][cH:34][c:33]1[CH3:36])[c:3]1[cH:4][n:5][c:6]2[n:7]1[n:8][cH:9][cH:10][cH:11]2

참가 물질

반응물 2

HCID 468387603-Ethynylimidazo[1,2-b]pyridazine

HCID 66736595N-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

생성물 1

HCID 24826879N-(4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide

출처 및 근거

ORD 기록: ord-74400b79e88e4f02bc7132a864236d34
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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