4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 5-chloro-N-[3-(dimethylamino)propyl]-N-methyl-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)nicotinamide
반응식
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.[Cl:19][C:20]1[C:21](Cl)=[N:22][CH:23]=[C:24]([CH:35]=1)[C:25]([N:27]([CH2:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])[CH3:28])=[O:26]>>[Cl:19][C:20]1[C:21]([O:18][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][N:9]=[C:8]3[NH:7][C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)=[N:22][CH:23]=[C:24]([CH:35]=1)[C:25]([N:27]([CH2:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])[CH3:28])=[O:26]참가 물질
3
실험 절차
Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol and 5,6-dichloro-N-[3-(dimethylamino)propyl]-N-methylnicotinamide, and in the same manner as in Example 65 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (58 mg) was obtained as a yellow amorphous solid.
출처 및 근거
- ORD 기록
- ord-09bbdaa1315c4ddc9a4772e2903b026d
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846700B2
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