M-Phenylenediamine → N1-(4-(pyridin-2-ylthio)pyrimidin-2-yl)benzene-1,3-diamine

반응식

Cl[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][N:3]=1.[C:15]1([NH2:22])[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=1>>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[S:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([NH:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([NH2:22])[CH:16]=2)[N:7]=1

참가 물질

반응물 2

HCID 7935M-Phenylenediamine

HCID 623418992-Chloro-4-(pyridin-2-ylthio)pyrimidine

생성물 1

HCID 68749996N1-(4-(pyridin-2-ylthio)pyrimidin-2-yl)benzene-1,3-diamine수율 30.1%

실험 절차

In a procedure analogous to Example 6, reaction of 2-chloro-4-(pyridin-2-ylthio)pyrimidine (100 mg, 0.45 mmol) and 1,3-phenylenediamine (193 mg, 1.78 mmol) furnished the product (40 mg, 30%).

출처 및 근거

ORD 기록: ord-2e164a36f5334bf1959405f5f75148fb
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846704B2

반응 노트

불러오는 중…