Benzenamine, 4-(4-morpholinyl)- → N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)acrylamide

HRID 81712

반응식

HRID 81712 반응식
Cl[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:19])[CH:17]=[CH2:18])[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[O:20]1[CH2:21][CH2:22][N:23]([C:26]2[CH:27]=[CH:28][C:29]([NH:30][C:2]3[N:7]=[C:6]([S:8][C:9]4[CH:10]=[C:11]([NH:15][C:16](=[O:19])[CH:17]=[CH2:18])[CH:12]=[CH:13][CH:14]=4)[CH:5]=[CH:4][N:3]=3)=[CH:31][CH:32]=2)[CH2:24][CH2:25]1

참가 물질

3

반응물 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 86645569N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide

생성물 1

HCID 59491751N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)acrylamide수율 43%

실험 절차

In a procedure analogous to Example 8, reaction of N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide (1.10 g, 3.77 mmol) and 4-morpholinoaniline (806 mg, 4.52 mmol) furnished the product (690 mg, 43%).

출처 및 근거

ORD 기록
ord-910c410461874acfbb00bd90348b422d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846704B2

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