Tetrahydrofuran → 8-(1-Ethyl-propyl)-3-(3-methoxy-5-pyridin-3-yl-thiophen-2-yl)-2,6-dimethyl-imidazo[1,2-b]pyridazine
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[Br:18][c:19]1[cH:20][c:21]([O:40][CH3:41])[c:22](-[c:24]2[c:25]([CH3:39])[n:26][c:27]3[n:28]2[n:29][c:30]([CH3:38])[cH:31][c:32]3[CH:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[s:23]1.[C:13]([Li:14])([CH3:15])([CH3:16])[CH3:17].[CH2:8]1[O:9][CH2:10][CH2:11][CH2:12]1.[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47].[I:1][c:2]1[cH:3][n:4][cH:5][cH:6][cH:7]1.[cH:48]1[cH:49][cH:50][c:51]([P:52]([Pd:53]([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[P:92]([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)([c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[c:117]2[cH:118][cH:119][cH:120][cH:121][cH:122]2)[cH:123][cH:124]1>>[c:2]1(-[c:19]2[cH:20][c:21]([O:40][CH3:41])[c:22](-[c:24]3[c:25]([CH3:39])[n:26][c:27]4[n:28]3[n:29][c:30]([CH3:38])[cH:31][c:32]4[CH:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[s:23]2)[cH:3][n:4][cH:5][cH:6][cH:7]1
